HIF1α is a key player in angiogenesis. VHL is a protein required for the degradation of HIF1α in the normal oxygen level. Loss-of-function mutations in the VHL gene have been found to promote tumor growth. Please explain why these mutations can promote tumor growth?

Answers

Answer 1

Answer:

Explanation:

The VHL gene is a tumour suppressor gene that regulates cell growth and cell death. This gene is also located on chromosome 3. It functions to prevent rapid proliferation of cells. For a person to develop tumor both copies of the gene must be mistake or altered allowing for a loss of function that prevents its from causing degradation of HIF1α in the normal oxygen level as its it normal function. This then allows for the survival of HIF1α that promotes amgiogenesis promoting tumor development.


Related Questions

What's the easiest
way to learn Krebs cycle?​

Answers

Answer:

"Our City IS Kept Safe And Secure From Mobsters"

Explanation: Capitals represent the first letter.

Oxalacete

Citrate

Isocitrate

Alpha-ketoglutamate

Succinyl-coA

Succinate

Fumarate

Malate

Answer:

Get diagrams and look at what is changing

Explanation:

What do cells have in common

Answers

Answer:

All cells have these four parts in common: a plasma membrane, cytoplasm, ribosomes, and DNA.

Explanation:

Answer:

All cells share four common components:  

a plasma membrane, an outer covering that separates the cell’s interior from its surrounding environment

 cytoplasm, consisting of a jelly-like region within the cell in which other cellular components are found

DNA, the genetic material of the cell

ribosomes, particles that synthesize proteins. However, prokaryotes differ from eukaryotic cells in several ways.

How do rivers become large as they travel across land

Answers

Answer:

groundwater rises, adding water to rivers. tributaries combine, adding water to rivers. ice sheets melt slowly, adding water to rivers. rainfall in an area increases, adding water to rivers.

Explanation:

The answer is B please mark me as brainliest

Question 5
One characteristic feature of tundra is that only the surface thaws in the summer
and refreezes in the winter, leaving a layer of permanently frozen subsoil. This
characteristic is known as
Your answer:
o alglaciation

Answers

Answer:

rjghghgh

Explanation:

What is the lava like that produces an eruption like this one? A. thin and runny B. thick and runny C. thick and sticky D. thin and rich in gas

Answers

it could be either A or B depending on how much it’s been

True or False: Population size influences the chances of a species surviving or going extinct, and smaller populations are more likely to go extinct.

Answers

Answer:

True

Explanation:

In my opinion it makes sense

can someone answer this

Answers

Answer:

B) 64

Explanation:

Can light cause changes to metal

Answers

Answer:

yes it can cause changes to metal

Answer:

No.

Explanation:

The metal can't change because light is not a physical thing. the metal can change by getting warm and/or changing color, because different types of light can cause different changes to a material when they are absorbed.

// have a great day //

name 2 nature subtopics

Answers

Answer:

mature world and universe

Explanation:

Identify the strengths and weaknesses of Mendel’s Law of Independent Assortment.

Answers

Answer:

Explanation:

Mendel propel two laws The law of inheritance and that of independent assortment of gene.

Independent assortment of gene explain that alleles of a gene assort independently and that different Allele can show different phenotypic effect and differences. This means that in a gene where we have 2 allele they can both show individual difference where one can have a dominant effect over the other and the other allele is recessive.

This law does not take care of linked gene where alleles don't separate after crossing over sister chromatids but are rather inherited together given rise to complex inheritance.

Pleiotrophy effect of a gene where a gene is having many effects.

explain the role microbiologist play in researching and treating the disease

Answers

Answer:

Microbiologists are essential in helping us to treat diseases. Many work as biomedical scientists in hospitals and laboratories: testing samples of body tissue, blood and fluids to diagnose infections, monitor treatments or track disease outbreaks.

why tropical rain forests contain a large variety of plants and animals.

Answers

Sorry If I misspell or have horrible grammar

Explanation :

Rainforests have a lot of plants and animals because ;

Climate : The rainforest(s) are in very tropical regions , meaning the recieve a lot of sunlight . The energy is stored in plant vegetation . Animals are attracted to the food and eat it .

Edit : Also I tried to put the answer I found into my own words , I noticed the 1st person copied and pasted an answer which is copying

Answer:Sample Response:

Tropical rain forests are warm and wet, and the temperature does not vary much. Because of this, a huge variety of plants can live in tropical rain forests. Because there are so many kinds of plants, there are habitats for many different kinds of animals as well.

Explanation:

plz give brainliest

Which of the following terms describes a lipid molecule that has only single
bonds between its carbon atoms?

Answers

Answer:

Saturated fatty acids have only single bonds between carbon atoms. As a result, the carbon atoms are bonded to as many hydrogen atoms as possible. In other words, the carbon atoms are saturated with hydrogens. Saturated fatty acids are found in fats.

The answer is Saturated

















































err, I think?

The bar chart shows the heights of pea plants grown from 500 pea seeds.What variation do the plants show?

A. Continuous variation only
B. Discontinuous variation only
C. Both continuous variation and discontinuous variation
D. Neither continuous variation and discontinuous variation

Answers

Answer:

C. Both continuous variation and discontinuous variation

Explanation:

this was the answer on my quiz a couple days ago

It's C. Both continuos variations and discontinuos variation

what consists of three stages

Answers

Answer:

Stages of what

Explanation:

which statement best describes how genes are able to produce a organism's traits?

Answers

Answer: Genes come in pairs which are passed down by the parents'. Both parents pass on one copy of their genes to create a gene for the child; this will later create a trait.

what are the molecules that make up the DNA rail?

Answers

DNA rails are made up of deoxyribose (sugar) and phosphoric acid.

PLSSS HELPPP MEEE WITH THIS QUESTIONNNNN NO GUESSING PLSSSS
Which process is shown in the plant cell below?

A= cell growth
B= cell reproduction
C= metamorphosis
D= photosynthesis

Answers

the answer is B = cell reproduction

The given process shown in the image is cell reproduction. Cell reproduction takes place by mitosis and meiosis.

What is cell reproduction?

Mitosis and meiosis are the two distinct processes of cell division. When people talk about "cell division," they typically mean mitosis, which is the process of creating new cells for the body. The cell division process known as meiosis is what produces egg and sperm cells.

A vital process for life is mitosis. A cell divides into two identical daughter cells after duplicating all of its components, including its chromosomes. Due to the importance of this procedure, specific genes carefully regulate each phase of mitosis.

Meiosis, the second sort of cell division, makes sure that each generation of people has the same number of chromosomes.

Therefore, The given process shown in the image is cell reproduction. Cell reproduction takes place by mitosis and meiosis.

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extinction occurs when the environment changes and

Answers

Answer:

a population dies out

Explanation:

when the environment changes causes the animals or living specimens to die out

How can chimpanzees have different traits from one another

Answers

Answer:

They have different genes just as humans do

Explanation:

Answer:

They have different genes just as humans do

Explanation:

In the previous activity, you chose an animal that interested you and listed three examples of innate behavior and three examples of learned behavior for that animal. Now research what, if any, courtship and mating rituals this animal has. Explain why you think it has or doesn’t have these behaviors.

Answers

Answer:

what grade

Explanation:

Courtship and mating rituals are diverse and can vary greatly among different animal species. They are typically involved in attracting mates, establishing pair bonds, and ensuring successful reproduction.

1. Courtship and Mating Rituals Exist: Many animal species have elaborate courtship and mating rituals. These behaviors can serve various purposes, such as displaying fitness and attractiveness to potential mates, establishing territory, or demonstrating parental abilities.

2. Absence of Courtship and Mating Rituals: Some animal species may not exhibit elaborate courtship or mating rituals. This can occur in species where mating opportunities are abundant or where the reproductive process is straightforward without the need for elaborate displays.

The presence or absence of courtship and mating rituals can depend on various factors, including ecological pressures, social structure, reproductive strategies, and evolutionary history of the species. Different species have evolved different strategies to maximize their reproductive success, and these strategies can manifest as complex courtship rituals or simpler methods of attracting mates.

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If the chromosomes line up
differently, how will this
affect the gametes formed?

Answers

The organism will have a disorder

suppose you are desigining a device to transmit information wirelessly. what part of the em spectrum will your device broadcast in and why ?

Answers

The device should broadcast in a pdf file so it can transfer information easier by tapping the link.

Can someone explain to me the groups of invertebrates, their characteristics, and their examples.

Answers

Answer:

invertebrates are animals that lack back bone like protozoans such as amobas and paramecia,annelids such as earth worm ,spongs, comb jellies ,hydras

Sponges, jellyfish, worms, snails, and squids. These are just a few of the many types of invertebrates.
...
Classification of Invertebrates.
Phylum (includes) Notable Characteristics Example
Arthropoda (insects, spiders, crustaceans, centipedes) segmented body, jointed appendages, exoskeleton, brain insect (dragonfly)
Hope it helps

Earth's moon _____. Has a thick atmosphere that protects it from asteroids rotates in the same amount of time that it revolves has more gravity than Earth is the largest satellite in the solar system

Answers

Answer:

The Earth moon rotates in the same amount of time that it revolves.

Explanation:

The moon is the only Earth's natural satellite and it orbit round the Earth. It is the fifth largest natural satellites. It was formed not long after the formation of the Earth. The moon rotates on its axis . The moon rotate once and it's matches the period it's orbit making it to keep the same side facing of the Earth. This means that the moon the moon rotates once every time it revolves the Earth.

Observations have led to all of the following except ___.

Answers

Answer: experimentation and then conversion of experiments into theories

Observations lead to form hypothesis and then deduction which are proved statistically by experiments

A student run10m/s what does it means

Answers

Answer:

it means that student is running 8meters per second

Answer:

it means that the student runs 10 miles per second

Explanation:

The heliocentric system gained support when Galileo observed that

Answers

Answer:

Venus goes through phases similar to those of Earth's moon. Hope this helps out.

Explanation:

Can light cause changes metal

Answers

Answer:yes

Explanation:Cause metal to be semi conductor

Answer:

yesssssssss!!!!!

Explanation:

Select the correct answer from the drop-down menu.
When multiple glaciers start their downward flow from a single point, they create a .

Answers

Answer:

They create a Mountain Peak

When multiple glaciers start their downward flow from a single point, they create a Mountain peak. So, the correct option is B.

What are Glaciers?

A glacier is a sizable, slowly moving mass of ice that develops over a considerable amount of time as a result of the buildup of snow and ice. In areas where the average temperature is below freezing and there is enough snowfall to offset the melting that takes place during the summer, glaciers can be discovered. They can occur at lower elevations in some places, although they are mainly found at high altitudes or in the polar regions.

When several glaciers begin to flow downward, they build something resembling a pyramid. The mountain peak is created as a result of the glacier's movement from a single location. Due to the simultaneous movement of several glaciers to the ground, a pointed structure has recently created.

Therefore, the correct option is B.

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Your question is incomplete, most probably the complete question is:

when multiple glaciers start their downward flow from a single point, they create a [mountain cliff] or [mountain peak]

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