Congenital hyperinsulinism is a rare condition in which infants experience frequent episodes of hypoglycemia. Based on the functions of the two main hormones that control blood sugar homeostasis, which of the following would be effective at treating the hyperinsulinemia?
A. Glucagon
B. Glucocorticoids
C. Preventing insulin release or production
D. All of the choices are correct.

Answers

Answer 1

Answer:

Any  treatment which involves reduction in the levels of insulin to curb excessive influx of glucose into the cells from the blood  will be an ideal treatments.

Glucagon, which converts excess glucose to glycogen. Glucocorticoids induces insulin resistance thus raises glucose levels.

suppressing insulin release will be another option.

Therefore all options are correct.

Explanation:


Related Questions

You come upon an outcropping of sandstone while working in the field in Southern Utah. You notice cross-beds. Which of the following would you be able to determine about this deposit, just from looking at it? Group of answer choices A.the complete mineral composition of the sandstone B.the direction of the wind at the time it was deposited C.the tectonic history of the deposit D.the origin of the sand in the deposit

Answers

Answer:

B. the direction of the wind at the time it was deposited

Explanation:

Cross beds refers to those rock beds which are formed due to the deposition of bed forms such as dunes. These cross beds are the group of inclined layer which is formed due to the flowing of water or wind. These rock beds represents the movement or direction of wind and water at the time of deposition and as a result cross beds are formed. So we can say that cross beds were formed due to the direction of wind.

reaaallly need help!!​

Answers

Explanation:

this is very easy I will try and send this picture

Anaplerotic reactions serve to:__________.
a) divert materials out of the citric acid cycle for use in biosynthesis.
b) regulate energy production by bypassing the citric acid cycle.
c) replenish the citric acid cycle if it becomes depleted of intermediates by biosynthetic demands.
d) produce pyruvate, which initiates the cycle when glucose degradation is not occurring.

Answers

Answer: Option C.

replenish the citric acid cycle if it becomes depleted of intermediates by biosynthetic demands.

Explanation:

Anaplerotic reactions that form intermediates for kreb cycle, citric cycle. They form intermediates for metabolic pathways like citric cycle. The citric cycle is important for energy production and biosynthesis. Anaplerotic reactions help to restore or replenish intermediates in citric cycle if there is depletion of intermediates biosynthetic demands.

ASAP PLEASEEE HELP ME
Remember monomers and polymers? DNA is what type of polymer?
A.) Protein
B.) Nucleic Acid
C.) Lipid
D.) Carbohydrate

Answers

Answer:

polynucleotide "carbon" sugar so I would say B or D

Explanation:

Some parts of the worlds rainforests haven’t been studied closely, and may contain species of plants which have benefits for humans. ‘Suggest and explain uses of stem cells taken from the meristem of a new species of plant.’

Answers

The following can be the uses of stem cells taken from the meristem of a new species of plant: To determine the resistance against various plant diseases:  Stem cells taken from the meristem can be specifically tested for their effectiveness against diseases that cause damage to parts like the roots, shoots and appendages of the plants. They can thus also be used to reconstruct the damaged plant tissues in case of the possibility of extinction of the species discovered.

To determine the similarity of stem cells of one species of plant with that of another: By determining the similarity between the stem cells taken from two different species, it can be identified whether there is a possibility of clowning, of giving birth to new and improved species of plants that are beneficial for mankind, or that of interchanging the stem cells to boost up or slow down the growth of the plants.

To determine whether the stem cells can be altered and reintroduced to make the plants grow in a specified manner:  By altering and modifying the stem cells and reintroducing them back again, it is possible to restrict the growth of the plant to a specific size or shape. This trait of the stem cells can be used to make the plantation possible in compact areas as well as to grow the plants in the desired shapes.

To determine whether the speed of division of cells at the roots and appendages of the plant can be modified: By restricting or boosting the speed of the division of meristem cells using modified stem cells, the plant can be made to grow faster in a specific season and slower in another. This feature can be used to lower the vulnerability of the plant species towards various natural weathering actions.

Stem cells extracted from the meristem can be precisely examined for their effectiveness against illnesses that harm portions of the plants such as the roots, shoots, and appendages to ascertain the resistance against various plant diseases.

What is meristem?

They can thus also be utilized to rebuild the damaged plant tissues if the newly discovered species becomes extinct.

It can be determined whether there is a chance of clowning, or of giving birth to new and improved species of plants that are beneficial to mankind.

Therefore, Stem cells extracted from the meristem can be precisely examined for their effectiveness against illnesses that harm portions of the plants such as the roots, shoots, and appendages to ascertain the resistance against various plant diseases.

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In the lab on Trophic Interactions you were looking at behavior of mosquito larvae. The question being asked was: Does prey behavior change in the presence of a predator? What would be an appropriate null hypothesis for this experiment? Recall in Treatments 2 and 3, a predator was added to the mosquito tanks.

Answers

Answer:

Null hypothesis: the behavior of mosquito larvae doesn't change in the presence/absence of predators added to the tanks in Treatments 2 and 3.

Explanation:

In statistics, the null hypothesis states that there are no differences between the two variables tested in the experiment, while the alternative hypothesis uses the experimental data in order to reject the null hypothesis. In this case, the alternative hypothesis will use the data from treatments 2 and 3 to confirm that predators can modify the behavior of mosquito larvae.

You have decided to examine the dynamic properties of a flagellum. After having isolated flagella from sea urchin sperms, you placed them into an aqueous buffer with a pH of 7.0. Very rapidly, however, you observed that the movement of the isolated flagella stopped. Which hypothesis are you likely to propose to explain that result?

Answers

Answer:

Osmosis

Explanation:

In this case, osmosis has occurred, and that is why the movement of the flagellum stops.

It should be understood that osmosis is the movement of substances from the region of lower concentration to the region of lower concentration through a semi- permeable membrane.

Which of the following removes waste from the body through perspiration? blood kidneys skin large intestine

Answers

Answer:

Kidneys, skin and large intestine. Organs of excretion include the skin, liver, large intestine, lungs, and kidneys. All of them excrete wastes, and together they make up the excretory system. The skin plays a role in excretion through the production of sweat by sweat glands.

Explanation:

Answer: SKIN

Explanation: Perspiration is the process of sweating so your skin does that

Match the words in the left column to the appropriate blanks in the sentences on the right. Make certain you have filled every blank with a term before clicking Submit.
Nairobi ______ is the capital of Norway.
Buenos The capital of Canada is______
Aires ______is the capital of Indonesia.
Canberra ______is the capital of Australia.
Ottawa The capital of Kenya is________
Jakarta The capital of Argentina is______

Answers

Answer:

Oslo is the capital of Norway.

The capital of Canada is Ottawa.

Jakarta is the capital of Indonesia.

Canberra is the capital of Australia.

The capital of Kenya is  Nairobi.

The capital of Argentina is Buenos Aires.

Explanation:

Oslo is the capital of Norway.

Being the biggest city of Norway, Oslo was made the capital of the country. It is also the most populous city in the country and is the main governmental and economical center of the nation.

The capital of Canada is Ottawa.

Chosen because of its location, the city of Ottawa was chosen by Queen Victoria to be the capital of Canada. It is the central point of access between the cities of Montreal and Toronto, and despite it's smaller status as a city, it was chosen as the capital due to its prominence in the location.

Jakarta is the capital of Indonesia.

Jakarta, located on the island of Java, is the capital of Indonesia. Formerly known as Batavia, this city was the official Dutch settlement during the colonial times. Now, it is presently the capital of the nation.

Canberra is the capital of Australia.

Despite Australia having numerous capital cities according to the boundary or seat of government it has, the city of Canberra is more regarded as the capital of the island nation. It is the largest inland city of the country and has numerous important government offices in it.

The capital of Kenya is Nairobi.

The biggest city in the Kenyan nation, the city of Nairobi is the capital of Kenya. The Nairobi River flows through the city, from which the Maasai name of the city Enkare Nairobi is attributed.

The capital of Argentina is Buenos Aires.

Buenos Aires is the capital of Argentina. It is also the largest city in the Latin nation and is home to numerous multi-nationals from various ethnic groups.

Which step of the scientific method do you perform after you collect data and
observations?

Answers

Answer: Draw a conclusion about your hypothesis

Explanation:

If the results match up, then the data supports the hypothesis and thus, the hypothesis itself SUPPORTS the idea that you're studying. Afterward, discuss the experiment with your peers.

Never say that a hypothesis has been proven, because you are not proving anything, it is support.

Female honey bees are diploid and male honey bees are haploid. The haploid males produce sperm and can successfully mate with diploid females. Fertilized eggs develop into females and unfertilized eggs develop into males. How does the process of sperm production in male honey bees differ from sperm production in other animals?

a. Male honey bees use meiosis I only, whereas other animals use both phases of meiosis.
b. Male honey bees use meiosis, whereas other animals use mitosis.
c. Male honey bees use mitosis, whereas other animals use meiosis.
d. Male honey bees can use mitosis or meiosis, whereas other animals can only use meiosis.

Answers

Answer:

The correct answer is option C.

Explanation:

In most of the male animals the production of sperms takes place through the process of meiosis. Meiosis occurs only in 2n or diploid cells. Thus the most of the animals produce sperm due to their diploid nature.

In male bees the sperm production is different than other animals as it is haploid cell and haploid cells produce sperms through mitosis. In haploid cells mitosis helps in produce more sperms.

Thus, the correct answer is option C.

what is evapraratio​

Answers

Answer:

Evaporation is the process by which water changes from a liquid to a gas or vapor, in other words evaporation is a type of vaporization that occurs on the surface of a liquid as it changes into the gas phase.

Some scientists who are Christians have developed a theory called ___________ to explain the creation and development of life on earth.

Intelligent Design
fossil formation
relativity

Answers

Answer:

Intelligent Design

Some scientists who are Christians have developed a theory called Intelligent Design to explain the creation and development of life on earth.

However, in my opinion its complete nonsense

During digestion fat is broken down into

Answers

Answer:

Lipase

Explanation:

Lipase enzymes break down fat into fatty acids and glycerol. Digestion of fat in the small intestine is helped by bile, made in the liver.

The first line of defense involves which structure(s)?
O T-cells
O skin
O blood
O B-cells
Mark this andretum
Next
Submit

Answers

Answer:

skin.

Explanation:

the first line of defense uses physical parts such as skin.

A negative control is a sample that you know will give you a negative result. You are testing for the presence of proteins, reducing sugars, starch, and lipids in various foods. What would be the best negative control for this experiment

Answers

Answer:

Starch and water will be the best negative control

Explanation:

Negative control sample is a sample that will not give change in an experiment.

Starch and water will be the best negative control. This is because, starch is broken down by HCl to monosaccharides in the Benedict test which is the test for reducing sugar

Distilled water remain a negative control because it remain blue which means it does not reduce sugar with starch solution.

Water plus us a negative control for Buiret test (protein) and Benedict(reducing sugar) because it does not indicate the presence of protein and reducing sugar.

24. Explain why water shortages occur frequently in
parts of New York State even though the water
supply is nearly constant. [1]

Answers

Answer:

Water is an essential element of life. Water is life and it has a lot of functions such as for drinking and other domestic purposes. There could however be water shortage in some parts of Nee York states as a result of country as a result of the effects of drought due to low amount of rainfall in the area.

There may also be issues with the various instruments which helps in the transport of water to homes which could also lead to the shortage.

Shortages occur frequently in parts of New York State even though the water supply is nearly constant as there are some issues with the water transport system and also low rainfall in some areas.

What is the way of water transportation?

There can be several methods by which water transportation can be made easy.

Methods of transportation are included under three categories:

Aqueducts: it involves pipelines, canals, tunnels and bridges. Container shipment: it involves tank truck, tank car, and tank ship. Towing: it includes a tugboat is used to pull an iceberg or a large water bag along behind it.

Shortages occur frequently in parts of New York State even though the water supply is nearly constant as there are some issues with the water transport system and also low rainfall in some areas.

Thus, this can be the reason behind water shortage in New York.

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How can you determine the optimum pH of an enzyme?

Answers

The optimal pH can be measured by looking at enzyme activity verses pH. Enzyme activity will increase up to a certain pH; above that pH, the enzyme activity will begin to fall.

You can determine the optimum pH of an enzyme by graphing its pH activity and studying the results.

Enzymes each perform differently in distinct environments. Some require lower pH to function, while others achieve maximum performance at higher pH levels.  

This relationship between the productivity of the enzyme and the pH can be studied and graphed. Once done, we can expect this graph to look like a parabola, increasing steadily until maxed, then gradually decreasing back to zero at the other extreme. The vertice of this parabola will give us the optimum pH for the enzyme.

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You are running an experiment to study seed germination and accidentally left a dish of seeds covered with a little water in a totally dark room. When you return a few days later, you notice that the seeds have sprouted long roots and long shoots. What was the source of most of the matter that makes up these roots and shoots?A. oxygen in the airB. carbon dioxide in the airC. water in the dishD. glucose in the seed

Answers

Answer:

D. glucose in the seed

Explanation:

Plants generally make their food through the process of photosynthesis in the presence of sunlight by utilizing carbon-dioxide and water and produces oxygen and carbohydrate.

But due to the absence of sunlight, plant will be unable to use carbon dioxide and water for photosynthesis and oxygen is a by-product.

So the reason of seed germination is the presence of glucose in the seed. Seeds generally germinate through the process of inhibition, that require uptake of water. Glucose works as energy source in humans and plants as well. sugar or glucose allow the seed to utilize the water and help foster its growth.

Hence, the correct option is D. glucose in the seed.

Where do sperm mature?
O A. Epididymis
O B. Urethra
O c. Seminiferous tubules
O D. Vas deferens

Answers

Answer:

A.

Explanation:

Sperm migrate from the seminiferous tubules to the epididymis.

the answer will be A
hope you get it right:))

In tomatoes, dwarf (d) is recessive to tall (D), and opaque (light-green) leaves (op) are recessive to green leaves (Op). The loci that determine height and leaf color are linked and separated by a distance of 7 m.u. For each of the following crosses, determine the phenotypes and proportions of progeny produced.
A. D Op/ d op*d op/d op
B. D op/ d Op*d op/d op
C. D Op/d op*D Op/op d op
D. D op/d Op*D op/d Op

Answers

Answer:

a). D Op / d op X d op / d op –Parents

as we know,

Distance (m.u.) = Recombination frequency (%)

D Op / d op genotype produces 4 types of gametes as below:

Recombinant gametes (7%):

D op = 3.5% ,    d Op= 3.5%

Non-recombinant gametes (93%):

D Op= 46.5% ,   d OP =46.5%

Genotype, d op / dop produces only one type of gametes, d op.

                                                    d op

D OP (46.5%)                    D OP/d op (46.5%) = Tall, green

D op (3.5%)                        D op/d op (3.5%) = Tall, opaque

d OP (3.5%)                        d OP/d op (3.5%)= Dwarf, green

d op (46.5%)                       d op/d op (46.5%) = Dwarf, opaque

b).  similarily D op / d Op X d op / d op –Parents

Distance (m.u.) = Recombination frequency (%)

D op / d Op genotype produces 4 types of gametes similarily as in case a,

Genotype, d op / dop produces only one type of gametes, d op.

                                                            d op

D OP (3.5%)                        D OP/d op (3.5%) = Tall, green

D op (46.5%)                       D op/d op (46.5%) = Tall, opaque

d OP (46.5%)                       d OP/d op (46.5%)= Dwarf, green

d op (3.5%)                          d op/d op (3.5%) = Dwarf, opaque

c).  D Op / d op X D Op / d op -----Parents

D Op / d op genotype produces 4 types of gametes as below:

Recombinant gametes (7%):

D op = 3.5% = 0.035 , d Op= 3.5%=0.035

Non-recombinant gametes (93%):

D Op= 46.5%=0.465 ,  d OP =46.5%=0.465

The table is attached for C.

d).  D op / d Op X D op / d Op –Parents

Distance (m.u.) = Recombination frequency (%)

siliarily as a, b, and c gametes are four with the same frequency and table for the answer is attached

Recombinant gametes (7%):

D op = 3.5% = 0.035 , d Op= 3.5%=0.035

Non-recombinant gametes (93%):

D Op= 46.5%=0.465 ,  d OP =46.5%=0.465

1. An oak tree is adapted to grow in a wood. Which of the following is NOT
true?

A)It has a large root system to absorb water and minerals
B)It has a large root system to anchod the tree
C)It has plenty of leaves to absorb sunlight
D)It loses its leaves in autumn to save food

Answers

Answer:

(B) it has a large root system to anchored the tree

Relaxation of the diaphragm muscle plays a major role in expanding the lungs.
True
False​

Answers

Answer:

False

Explanation:

You relax the diaphragm muscle by exhaling. When the diaphragm muscle is relaxed, the lungs contract. When the diaphragm muscle expands, the lungs also expand. Therefore, relaxation of the diaphragm muscle does NOT play a major role in expanding the lungs.

Building large manufacturing facilities can affect
ecosystems by increasing the

Answers

Answer:demand for resources such as fossil fuels

Explanation:

Building large manufacturing facilities can affect ecosystems by increasing the demand for resources such as fossil fuels.

Thus, The breakdown of buried, carbon-based organisms that perished millions of years ago produces fossil fuels. They produce deposits rich in carbon, which are taken out and burned to provide energy.

They presently provide about 80% of the world's energy and are non-renewable. A vast array of items, including plastic and steel, are also produced using them. Coal, oil, and gas are the three forms of fossil fuels.

Global warming is mostly caused by emissions from fossil fuels, according to the Intergovernmental Panel on Climate Change (IPCC). 89% of the world's CO2 emissions in 2018 came from industry and fossil fuels.

Thus, Building large manufacturing facilities can affect ecosystems by increasing the demand for resources such as fossil fuels.

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Sensory information from proprioceptors about joint and muscle positions are carried to the brain by the: Sensory information from proprioceptors about joint and muscle positions are carried to the brain by the: anterolateral system (spinothalamic tracts). vestibulospinal tract. reticulospinal tract. spinocerebellar tracts.

Answers

Answer:

Spinocerebellar tracts.

Explanation:

Spinocerebellar tracts are afferent neurons that transmit proprioceptive information from the peripheral nervous system ( muscles and joints propricetors) to the cerebellum. It originated from the spinal cord and end at the cerebellum. It carry unconscious proprioceptive sensory information from the muscles, organs to the cerebellum.

You have isolated a new mutation in the T4 bacteriophage rII A gene and you map its location within the gene by recombination frequency. You find that this new mutation fails to give wild type recombinants with several different adjacent mutations located in the same gene. What type of mutation is this new one you just isolated

Answers

Answer:

A lethal mutation, thereby the resulting phenotype is not observed .

Explanation:

Lethal mutations are the result of genomic changes that may be lethal in certain conditions. In genetic research, this type of mutation has shown to be very useful in analyzing gene function (i.e., genes whose protein products are key for the survival of the organism in question), and they are perfect gene markers. In bacteriophages, for example, temperature-sensitive mutants of phage T4 that can not grow at temperatures higher 42°C have been identified (Edgar & Lielausis 1964).

Citation:

R. S. Edgar, & I. Lielausis (1964). Temperature-sensitive mutants of bacteriophage T4D: their isolation and genetic characterization. Genetics, 49(4), 649.

01:50:51
A scientist discovers a cell that has chloroplasts, cytoplasm, DNA, and a cell membrane. Which statement best describes how
the cell could be classified?
The cell is prokaryotic her
has DNA

Answers

The cell is a plant cell as animal cells do not have chloroplasts

Answer:

The answer is D.) The cell is eukaryotic because it has chloroplasts.

TP53 is a recessive gene and is not located on the X chromosome, why would people who inherit just one mutant copy of a recessive tumor-suppressor gene be at higher risk of developing cancer than those without the recessive gene?

Answers

Answer:

Explanation:

Since it is a recessive gene, tumor suppressor genes required the inactivation of both alleles, this is usually accomplished by the mutation of one allele and a targeted homozygous deletion of the second allele. This leads to an effective inactivation of the suppressor genes with the mutations acting a a dominant negatives. This way, patients are put at a higher risk of developing cancer

If the current trend continues, can the temperature be expected to increase/decrease or stay the same in the next twenty years? Anssssswer please only 8 minutes left !!!

Answers

Answer:

Increase

Explanation:

Which type of mutation is likely to have the least affect on an organism

Answers

Answer:

Point Mutations

A point mutation—the change of a single nitrogen base in a DNA sequence—is usually the least harmful type of DNA mutation

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In 'Children's Song' how does the poet present the ways children see their own secretworld? (24 marks] A gym charges $45 per month and a $75 one-time starting fee. Which of thesewill show how much it costs to join the gym for one year? 5Select the correct answer.A consumer goods company sold 5 million units of its latest product in the last quarter. The company's sales director wants the marketingexecutive, David, to write about the company's achievement and convey the information to all employees. Which type of business writing sheDavid use?A proposalB.newsletterC. presentationD.memoResetNext (3+4x)(3-4x)=THIS IS SO HARD IM GOING CRAZY !!!!!!!!!!!! Please help me with my Algebra. :) Only one QUESTION I NEED HELP SO BAD I WILL MOST DEFINITELY GIVE BRAINLIEST AND 30 POINTS PLEASE IT'S DUE TODAY Miranda sat in the high school computer lab typing like mad. It was 8:30 a.m., and her 1,000-word report on The Catcher in the Rye was due at 9:00. For the past hour, she had been flipping through the ratty pages of the old paperback trying to discern the major plot points and then typing out a few sentences that she hoped were logical. The only reason she was able to get into the lab that early was because she was one of Mrs. Brodys assistants, but a couple of hours in the lab didnt make up for weeks of zoning out in English class.Miranda could kick herself, but she was too busy skimming through her notes and attempting to remember somethinganything!that Mr. Giuffreda had talked about. Mr. Giuffreda was a tough grader, and Miranda did not work well under pressurenot a great combination. On top of all that, Miranda could hear her mothers voice in her head: One more bad grade in English, young lady, and no more soccer team. Miranda failed to see the relationship between soccer and book reports, but she also knew her mother wasnt kidding. 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Mirandas fingers were still flying, but by 8:59, Mrs. Brody asked Miranda to leave so she could start class on time. Miranda saved her work on her USB drive, collected her pages from the printer, and slung her knapsack over her shoulder. Then she trudged down the hall to Mr. Giuffredas class as slowly as possible, even though she knew she would be late and would probably get detention.10Select the correct answer.Based on the passage, what will Mirandas mother probably do?A. find someone to tutor Miranda in EnglishB. ground Miranda for the next two weeksC. force Miranda to quit the soccer teamD. understand that Miranda tried her best 1. What is the main idea in High Incomes Don't Bring You Happiness"|| The last Americans to leave South Vietnam were evacuated byfrom the U.S. embassy.o helicopteroboatO trainO plane Omar and Caleb each had a repair made on their cars. The initial cost of each repair is $1,000. Omar and Caleb each have two coupons. Each of them uses both of his coupons toward the cost of the repair. One coupon is for $80 off the repair cost. The other coupon is for 15% off the repair cost. Omar and Caleb use their coupons in a different order, as shown below. Some amount of marbles were arranged in an equilateral triangle. And 2 marbles were extra. When the same set of marbles were arranged into triangle in which each side has one more marble than in the first arrangement there were 13 marbles shortage. How many marbles were in the set? Tanya and Reece each walked 4 miles on Monday. Reese also walked 4 miles on Tuesday and 4 miles on Wednesday . How many miles did Reece walk 2 PointsWhich of the following is a geometric sequence?O A. 2,5, 7, 12, 19B. 2, 4, 8, 16, 32C. 3, 6, 9, 15, 24O D. 6, 13, 20, 27, 34 Solve the following equation. Then place the correct number in the box provided. 7x/15-1=22 x=? To practice Problem-Solving Strategy 6.1: Circular motion A highway curve with radius R = 274 m is to be banked so that a car traveling v = 25.0 m/s will not skid sideways even in the absence of friction. At what angle should the curve be banked? Suppose that General Motors Acceptance Corporation issued a bond with 10 years until maturity, a face value of $ 1 comma 000, and a coupon rate of 7.0 % (annual payments). The yield to maturity on this bond when it was issued was 6.0 %. What was the price of this bond when it was issued? A chemistry student is given 600. mL of a clear aqueous solution at 37 C. He is told an unknown amount of a certain compound X is dissolved in the solution. The student allows the solution to cool to 21 C. At that point, the student sees that a precipitate has formed. He pours off the remaining liquid solution, throws away the precipitate, and evaporates the water from the remaining liquid solution under vacuum. More precipitate forms. 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B) Blue Corporation obtained significant influence over Hunsaker Company by buying 30% of Hunsakers 120,000 outstanding shares of common stock at a cost of $18 per share on January 1, 2020. On May 15, Hunsaker declared and paid a cash dividend of $120,000. On December 31, Hunsaker reported net income of $220,000 for the year. Prepare all necessary journal entries for 2017 for (a) Edelman and (b) Wen.